Search results for " acetylcholinesterase"

showing 3 items of 3 documents

Antioxidant activity and enzymes inhibitory properties of several extracts from two Moroccan Asteraceae species

2018

Abstract The present work reports investigation on phenolic compounds, antioxidant activity and enzyme inhibitory activities (acetylcholinesterase, butyrylcholinesterase, tyrosinase, α-amylase and α-glucosidase) of different extracts from two Moroccan Asteraceae species; Bubonium imbricatum Cav. and Cladanthus arabicus (L.) Cass. B. imbricatum extracts contained the highest amounts of phenolics and flavonoids, and also exhibited higher antioxidant activity. In this species, the highest total phenolic (1611.13 ± 14.23 μmolGAE/gextract) and flavonoid (376.11 ± 8.22 μmolQE/gextract) contents were observed in aqueous-methanol extract obtained by maceration. Further, UHPLC–MS analysis of C. arab…

0106 biological scienceschemistry.chemical_classificationABTSSettore CHIM/10 - Chimica Degli Alimenti010405 organic chemistryDPPHTyrosinaseFlavonoidAcetylcholinesterase; Bubonium imbricatum Cav.; Butyrylcholinesterase; Cladanthus arabicus (L.) Cass.; Phenolics; Tyrosinase; α-Amylase; α-Glucosidase; Plant SciencePlant Science01 natural sciencesDiosmetin0104 chemical scienceschemistry.chemical_compoundBubonium imbricatum Cav. Cladanthus arabicus (L.) Cass. Phenolics Acetylcholinesterase Butyrylcholinesterase Tyrosinase α-Amylase α-GlucosidasechemistryApigeninMaceration (wine)Food scienceLuteolin010606 plant biology & botany
researchProduct

Acetylcholinesterase inhibitors and memantine in bipolar disorder: A systematic review and best evidence synthesis of the efficacy and safety for mul…

2016

Abstract Background Acetylcholinesterase inhibitors (AceI) and memantine might prove useful in bipolar disorder (BD) given their neuroprotective and pro-cognitive effects, as highlighted by several case reports. We aimed to systematically review the efficacy and safety of AceI and memantine across multiple outcome dimensions in BD. Methods Systematic PubMed and SCOPUS search until 04/17/2015 without language restrictions. Included were randomized controlled trials (RCTs), open label studies and case series of AceI or memantine in BD patients reporting quantitative data on depression, mania, psychotic symptoms, global functioning, or cognitive performance. We summarized results using a best-…

Malelaw.inventionpsychosis.0302 clinical medicinePiperidinesRandomized controlled triallawDonepezilDonepezilRandomized Controlled Trials as Topicbipolar disorderClinical Trials as TopicEvidence-Based MedicineDepressionMemantineMiddle AgedManiaPsychiatry and Mental healthClinical PsychologyTreatment Outcomeacetylcholinesterase inhibitorsdepressionIndansFemalemedicine.symptomPsychologyManiamedicine.drugAdultmedicine.medical_specialtyBipolar disorderPlaceboBipolar disorder Acetylcholinesterase inhibitors Memantine Depression Mania Psychosis03 medical and health sciencesmaniaMemantineInternal medicinemedicineGalantamineHumansBipolar disorderAcetylcholinesterase inhibitors; Bipolar disorder; Depression; Mania; Memantine; Psychosis.PsychiatryDepressive DisorderGalantaminePsychosismedicine.disease030227 psychiatryAcetylcholinesterase inhibitorsMoodPsychotic DisordersAcetylcholinesterase inhibitors; Bipolar disorder; Depression; Mania; Memantine; Psychosis; Psychiatry and Mental Health; Clinical PsychologyCase-Control StudiesmemantineCholinesterase InhibitorsExcitatory Amino Acid Antagonists030217 neurology & neurosurgeryJournal of Affective Disorders
researchProduct

Heterocyclic Scaffolds for the Treatment of Alzheimer's Disease

2016

Background: The treatment and diagnosis of Alzheimer’s Disease (AD) are two of the most urgent goals for research around the world. The cognitive decline is generally associated with the elevated levels of extracellular senile plaques, intracellular neurofibril- lary tangles (NFTs), and with a progressive shutdown of the cholinergic basal forebrain neurons transmission. Even if several key targets are under fervent investigation in the cure of AD, till now, the only approved therapeutic strategy is the treatment of symptoms by using cholinesterases inhibitors. It has been demonstrated that both acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) enzymes are not only responsible of…

Pathologymedicine.medical_specialtyTau proteinDisease010402 general chemistry01 natural scienceschemistry.chemical_compoundAlzheimer DiseaseHeterocyclic CompoundsDrug DiscoverymedicineAnimalsHumansSenile plaquesCognitive declineButyrylcholinesterasePharmacologybiologyMolecular Structure010405 organic chemistryChemistryAcetylcholinesterase0104 chemical sciencesbiology.proteinCholinergicNeuroscienceAmyloid precursor protein secretaseAlzheimer’s disease amyloid-peptide secretase acetylcholinesterase tau protein heterocycles
researchProduct